While vacationing in the Ozark Mountains, Bugs Bunny encounters Curt and Pumpkinhead Martin, two dimwitted hillbillies who are duped by Bugs into a violent square dance.
On Halloween night, Bugs Bunny, masquerading as a witch, trick-or-treats at the creepy old mansion of Witch Hazel, who prides herself on being the ugliest witch of all.
Mama Buzzard wants her children to learn to bring back meat for dinner. One buzzardling is shy and has to be kicked out of the nest. He's told to at least bring back a rabbit.
In the Western town of Rising Gorge, Bugs faces off against Yosemite Sam, "the roughest, toughest, he-man stuffest hombre who's ever crossed the Rio Grande."
At Eureka Experimental Hospital, a doctor plans to switch the characteristics of a chicken into the brain and a rabbit, into each other. Bugs Bunny was registered as the experimental rabbit, Number 46.
Bugs Bunny finds that gangsters Rocky and Mugsy have chosen his new abode, a condemned building, as their hideout. Bugs manipulates them into attacking each other to prove that crime doesn't pay.
Bugs is the test rabbit shot to the moon. There, he meets Commander X-2, who is intent on destroying the Earth with his Aludium Q-36 Explosive Space Modulator.