A young man just released from a reformatory moves to a new neighborhood with his sister, intending to start a new life. However, he gets mixed up with the local mob boss and corrupt politicians and soon finds himself being framed for an arson and murder he didn't commit.
A street kid has dreams of becoming a jockey. He gets his chance when he and his gang discover a poor old man who has a championship race horse. The man agrees to let the boy ride his horse in a race, but first the gang must get enough money to pay for the race's entry fees.
The East Side boxing champion Muggs answers a challenge to a fight against the West Side champ but just before the match he is kidnapped. His friend Danny Lyons takes his place and wins the fight, only to have Mugs believe that Danny was responsible for his kidnapping.
A small town man inherits a significant fortune and takes his family to New York City whereupon they are continually shocked at the alien culture of the Big Apple.
Muggs is tricked into entering a Civilian Conservation Corps camp by Danny in order to get in shape. Muggs resists and battles with the camp captain and with other campers. He also becomes involved in trying to help one of his friends get out of trouble.
Sach learns that he has inherited a farm in rural hillbilly country, and when he and the Boys arrive there, they find themselves mixed up with a hillbilly clan named Smith who'll shoot anybody named Jones, plus a gang of bank robbers.
Sach is the exact double of a famous French scientist who has invented a powerful rocket fuel. Enemy agents, mistaking Sach for the scientist, attempt to kidnap him and get the formula for the fuel.
An electric shock enables Sach to predict numbers, so the Bowery Boys are off to Las Vegas to win enough money at the roulette wheels to let their landlady buy an apartment building. Witnessing his winning streak, some gangsters decide to move in and find out his "system" for beating the odds.
Slip and Sach take the rap for a robbery they did not commit in order to uncover the real robbers, whom they suspect are led by a convict who gives orders to his gang outside via a short-wave radio stashed somewhere in the prison.
The boys buy a uranium mine out west, but when they get there they find that it's pretty much worthless. However, the local badmen are distrustful of these new strangers, and when they mistakenly get the impression that the mine is loaded with uranium, they hatch a scheme to get rid of the boys and...
