Laurence Renoux, chef du service des maladies tropicales et infectieuses dans un hôpital parisien, est inquiète. Depuis quelques jours, elle est confrontée à une épidémie de source inconnue dont les symptômes s'apparentent à une méningite fulgurante, et qu'elle ne parvient pas à endiguer.
Pierre-Jean Morin, known as PJ, is a local police officer who falls in love with Lucille, the new recruit of his brigade. Often bullied by her colleagues, the young woman thinks of resigning. PJ will then do everything to keep her by his side...
Estelle, 30, thinks she is going to remain single for the rest of her life. A free-lance journalist, she also thinks she will never cover any news bigger than fillers. One day, Estelle sees her chance when she gets to interview soccer superstar Stefano Paudretto... only to ruin it all by slapping...