In 1458, five years after the fall of Constantinople to the Turk, eighteen cardinals meet to elect a new pope. Rodrigo Borgia, a 27 year old cardinal learns to play a very dangerous game.
In the small town of Seacliff, Wash., a child's letter to Santa Claus captures the nation's attention. When the little boy, Chris, writes that he wishes to leave this world so he will no longer be a burden to his divorcing parents, a race begins to find him before he harms himself.
Fugitive security guard Stanley Tweedle, love slave Zev Bellringer, and love slave robot head 790 are thrown together by fate and on the run from His Divine Shadow after stealing The Lexx: the most powerful destructive force in two universes.