A young man finds out that he holds the key to restoring hope and ensuring survival for the human race, while an alien species called the Drej are bent on mankind's destruction.
After a car crash sends repressed cartoonist Stu into a coma, he and the mischievous Monkeybone, his hilarious alter-ego, wake up in a wacked-out waystation for lost souls. When Monkeybone takes over Stu's body and escapes to wreak havoc on the real world, Stu has to find a way to stop him before...