Jimmy Quinn is a veteran of stand-up comedy's glory days; he is also an alcoholic. His life changes when his son David, who he abandoned as a child, shows up at his door, professing his desire to be a stand-up comedian.
The time is the early 21st century and a genetics lab has been destroyed in a fire seriously injuring a scientist and possibly killing his daughter. As two investigators begin to unravel the story of the lab and its experiments, they discover that the scientist may have started the fire himself...
A bartender with a fear of commitment has limited his social life to a weekly poker game with the guys. His best friend sets him up with a sure thing one night stand, and the two fall in love.