Arrogant, self-centered movie director Guido Contini finds himself struggling to find meaning, purpose, and a script for his latest film endeavor. With only a week left before shooting begins, he desperately searches for answers and inspiration from his wife, his mistress, his muse, and his mother.
She's a divorce lawyer, single mother and perpetually at war against men, he is a couple's therapist, single and not looking, they meet and collide in a bourgeois and romantic Rome...
Two cousins haven't spoken for almost twenty years, thanks to the enmity that their fathers feel toward one another. But an accident suddenly brings the cousins back together and thrusts them deep into the heart of the mafia.
A talent agent with a truly talentless client roster, Ercole Preziosi finds himself in trouble when a car crash injures his star comedian, so he turns to his young plucky driver to do stand-up duty.