After the death of a United States Senator, idealistic Jefferson Smith is appointed as his replacement in Washington. Soon, the naive and earnest new senator has to battle political corruption.
Boston pharmacist Tom Craig comes to Sacramento, where he runs afoul of local political boss Britt Dawson, who exacts protection payment from the citizenry. Dawson frames Craig with poisoned medicine, but Craig redeems himself during a Gold Rush epidemic.
It is 1915 in Vienna and the Great War has caused many casualties. Elsa, a beautiful prostitute, wants to help the war effort, but is rejected as a nurse, but a government official thinks that she will make an excellent spy.
After a payroll robbery the Mesquiteers catch up with the gang. But the members escape, the gang leader is killed, and they end up with only the leaders young son who is quickly sent to a work farm. They adopt the boy hoping to learn where the money is. Just as their kindness is about to pay off a...
The Rough Riders are after a gang of rustlers. Marshal Roberts is posing as a wanted outlaw, McCall is the Marshal supposedly after him, and Sandy is on hand as a cook. Roberts hopes his joining the gang will help bring them in.
Daggett is out to stop the completion of an oil well. He cheats Foster at poker and then forces him to delay the drilling. But the Mesquiteers are on the job with Lulaby posing as a cleaning lady to get evidence.
