Sniffles the mouse and his friend the Bookworm decide to take up egg collecting, setting their eyes upon a big barn owl egg. But the big barn owl isn't so hot on the idea.
Sniffles the mouse has to get an owl's egg for a scavenger hunt, but once he's gotten it, the egg hatches and draws the attention of the mouse-eating father owl.
A little cat must take his sick father's place as night watchman, but is bullied by a tough mouse and his gang, leaving the rest of the mice free to eat all the food and stage a musical floor show.
Sniffles the mouse, in his first appearance in a Warner Bros. cartoon, goes to a drugstore and gets drunk on a cold remedy, then befriends an electric razor and gets it drunk as well.
Momma's singing "Three Little Kittens" with her brood, but Blackie thinks it's for sissies and he'd rather listen to crime dramas on the radio. Momma sends him to bed, where he dreams of venturing out. He sees a sign looking for boys, no experience needed. It's Fagin's school, where he trains boys...
The mice are on the loose after hours in a doctor's office, playing with the various pieces of medical apparatus. Susie Mouse is caged for research until her lover Johnnie frees her. A mouse orchestra plays a swinging wedding song. But throughout, a cat is stalking...
Tom's father mistakenly believes that the little bird who's just rescued his tiny son from drowning in the dishwater is attacking the boy and drives it away. Tom sets off to find the bird and gets lost in a fierce snowstorm.
When his car breaks down out in the country, Sniffles the mouse takes shelter in an old mill, where he meets up with "Batty," a non-stop-talking little bat who later save Sniffles from a hungry cat.